JoVE Tutorials
These popular videos were published in the Journal of Visualized Experiments and serve to explain both the principles and techniques behind various biomedical science procedures. Visiting the JoVE page yields not only the background, protocols, and explanations for each topic, but also includes recorded techniques to aid others in replicating and expanding on each set of experiments.
Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
Generation of Stable Transgenic C. elegans Using Microinjection
Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson’s Disease Genes
Worm “Seizure” Movies
These and other videos are published as Williams et al. (2004) “Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabiditis elegans” Hum. Mol. Genet. 13:2043-2059. They are available at the journal website for Human Molecular Genetics. An international press release on this work is available via the Howard Hughes Medical Institute.
Quicktime video of C. elegans lis-1 mutants exhibiting epileptic-like convulsions in the presence of PTZ.
Quicktime video of a C. elegans unc-43 (calmodulin kinase II) mutant exhibiting epileptic-like convulsions in the presence of PTZ.
Embryonic Cell Division Movies
Quicktime video of wild-type C. elegans embryo undergoing its initial cell division.
Quicktime video of nud-1 RNAi-treated C. elegans embryo.
Quicktime video of lis-1 RNAi-treated C. elegans embryo
