Publications
49. Brad S. Pierce*, Allison N. Schmittou, Nicholas J. York, Ryan P. Madigan, Paula F. Nino, Frank W. Foss, Jr, Molly M. Lockart ”Improved resolution of 3-mercaptopropionate dioxygenase active site provided by ENDOR spectroscopy offers insight into catalytic mechanism” J Biol Chem. 2024 (In Press) Link
48. Mohsen Teimouri, Selvam Raju, Edward Acheampong, Allison N. Schmittou, Bruno Donnadieu, David O Wipf, Brad S. Pierce, Sean L Stokes, Joseph P Emerson* “Aminoquinoline-based Tridentate (NNN)-Copper Catalyst towards C—N bond forming reactions from Aniline and Diazo compounds” Molecules2024, 29(3), 730 Link
47. Mitu Sharma; Amanda Perkins; Raymond Awoyemi; Allison Schmittou; Selvam Raju; Brad S. Pierce; Bruno Donnadieu; David Wipf; Sean Stokes; and Joseph Emerson*;“Three water-soluble copper(II) N-heterocyclic carbenecomplexes: Toward copper-catalyzed ketone reduction under sustainable conditions” Dalton Trans2024 (Advance Article) Link
46. Jiemin Shen, Gang Wu, Brad S. Pierce, Ah-Lim Tsai*, Ming Zhou* “Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1” J Biol Chem.2023 299 (7) 104897. Link
45. Allison N. Schmittou, Yasmeen J. Solano, Philip D. Kiser, Brad S. Pierce* “3-mercaptopropionate dioxygenase (MDO)” Encyclopedia of Inorganic and Bioinorganic Chemistry2023. DOI: 10.1002/9781119951438.eibc2835 Link
44. Nicholas J. York, Molly M. Lockart, Allison Schmittou, and Brad S. Pierce* “Cyanide replaces substrate in obligate-ordered addition of nitric oxide to the non-heme mononuclear iron AvMDO active site” J Biol Inorg Chem. 2023, 28, pages 285–299. Link
43. Manuel Quiroz, Zachary Martinez, Molly M. Smith, Shaik Waseem Vali, Dakota Jones, Kim R. Dunbar, Michael B. Hall, Brad S. Pierce, and Marcetta Y. Darensbourg*; “Magnetic Coupling between Fe(NO) Spin Probe Ligands Through Diamagnetic NiII, PdII and PtII Tetrathiolate Bridges” Chemical Science2023, 14, 9167-9174. Link
42. Manuel Quiroz, Molly M. Lockart, Mohamed R. Saber, Shaik Waseem Vali, Lindy C. Elrod, Brad S. Pierce, Michael B. Hall, and Marcetta Y. Darensbourg* “Cooperative Redox and Spin Activity from Three Redox Congeners of Fe-Ni Complexes Comprised of Iron Nitrosyl and Nickel Dithiolene” Proc Natl Acad Sci U S A. 2022 119, 25. Link
41. Jenifer S. Calvo, Nicholas J. York, Ewelina Stefaniak, Wojciech Bal, Brad S. Pierce and Gabriele Meloni* “Evidence for a long-lived, Cu-coupled and oxygen-inert disulfide radical anion in the assembly of a metalloprotein Cu(I)4-thiolate cluster” J Am Chem Soc. 2022, 144, 2, 709-722. Link
40. Nicholas J. York, Molly M. Lockart, Brad S. Pierce* “Low-spin cyanide complexes of 3-mercaptopropionic acid dioxygenase (MDO) reveal impact of outer sphere SHY motif residues” Inorganic Chem.2021, 60, 24, 18639–18651. Link
39. Subhash Chand*, Sriparna Ray, Poonam Yadav, Susruta Samanta, Brad S. Pierce, and Roshan Perera “Abiological Catalysis by Myoglobin Mutant with a Genetically Incorporated Unnatural Amino Acid” Biochem J. 2021478(9)1795-1808. Link
38. Molly M. Lockart, Kyle C. Edwards, John B. Vincent*, and Brad S. Pierce* “Electron Paramagnetic Spectrum of Dimanganic Human Serum Transferrin” Polyhedron2021203, 115224. Link
37. Nicholas J. York, Molly M. Lockart, Sinjinee Sardar, Nimesh Khadka, Wuxian Shi, Ronald E. Stenkamp, Jianye Zhang, Philip D. Kiser*, and Brad S. Pierce* “Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center” J Biol Chem2021 296, 100492. Link
36. David M. Freire, Debora Beeri, Kristof Pota, Hannah M. Johnston, Philip Palacios, Brad S. Pierce, Benjamin Sherman, Kayla N. Green*; “Hydrogen Peroxide Disproportionation with Manganese Macrocyclic Complexes of Cyclen and Pyclen” Inorg Chem Front. 2020 7, 1573-1582. Link
35. Pawan Thapa, Philip M. Palacios, Brad S. Pierce, Frank W. Foss, Jr.*; “Synthesis of 1,2-Disubstituted Benzimidazoles by Iron Catalyzed Cross-Dehydrogenative-Coupling of Various ortho-Phenylenediamines” J Org Chem.2020 85, 4, 1991-2009. Link
34. Sinjinee Sardar, Andrew Weitz, Michael P. Hendrich, and Brad S. Pierce*; “Outer-Sphere Tyrosine 159 within the 3-Mercaptopropionic Acid Dioxygenase S-H-Y Motif Gates Substrate-Coordination Denticity at the Non-Heme Iron Active Site” Biochemistry 2019 58 (51) 5135-50. Link
33. Pawan Thapa, Esai, Corral, Sinjinee Sardar, Brad S. Pierce, and Frank Foss, Jr.*; “Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidationof Isoindolines” J. Org Chem, 2019 84, 2, 1015-1025. Link
32. Parham Asgari, Yuanda Hua, Apparao Bokka, Chanachon Thiamsiri, Watcharapon Prasitwatcharakorn, Ashif Karedath, Xin Chen, Sinjinee Sardar, Kyung Suk Yum, Gyu Leem, Brad S. Pierce, Kwangho Nam, Jiali Gao, and Junha Jeon*; “Catalytic Hydrogen Atom Transfer from Hydrosilanes to Vinylarenes by Alkali Metal Lewis Base Catalyst for Hydrosilylation and Polymerization” Nature-Catalysis.2019 2, 164-173. Link
31. Manuel Quiroz, Shengda Ding, Pokhraj Ghosh, Nattamai Bhuvanesh, Chung-Hung Hsieh, Philip M. Palacios, Brad S. Pierce, Marcetta Y. Darensbourg*, and Michael B. Hall* “Structural and Electronic Responses to the Three Redox Levels of Fe(NO)N2S2-Fe(NO)2” Chem Eur J. 2018, 26:24(60), 16003-08. Link
30. Madushani Dharmarwardana, André F. Martins, Zhuo Chen, Philip M. Palacios, Chance Nowak, Raymond P. Welch, Shaobo Li, Michael A. Luzuriaga, Leonidas Bleris, Brad S. Pierce, A. Dean Sherry, Jeremiah J. Gassensmith* “Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor” Molecular Pharmaceutics 2018 2973-83. Link
29. Samantha Brewer, Philip M. Palacios, Hannah Johnson, Brad S. Pierce, and Kayla Green* “Isolation and Identification of the Pre-Catalyst in Iron-Catalyzed Direct Arylation of Pyrrole with Phenylboronic Acid” Inorg Chem Acta. 2018 478, 139-147. Link
28. Subhash Chand; Sriparna Ray; Eranda Wanigasekara; Poonam Yadav; Joshua A. Crawford; Daniel W. Armstrong; Krishnan Rajeshwar*; and Brad S. Pierce* “Improved Rate of Substrate Oxidation Catalyzed by Genetically-Engineered Myoglobin” Arch Biochem Biophys2017 639, 44-51. Link
27. William P. Morrow, Sinjinee Sardar, Pawan Thapa, Mohammad S. Hossain, Frank W. Foss Jr. and Brad S. Pierce* “Thiol dioxygenase turnover yields benzothiazole products from 2-mercaptoaniline and O2-dependent oxidation of primary alcohols” Arch Biochem Biophys.2017 631, 66-74. Link
26. Sukanya Chaipayang; Chomphunuch Songsiriritthigul; Chun-Jung Chen; Philip M. Palacios, Brad S. Pierce; Sompong Klaynongsruang*; “Cloning, purification and structural characterization of Crocodylus siamensis ovotransferrin for insight into functions of iron binding and auto-cleavage” Comparative Biochemistry and Physiology – Part B: Biochemistry & Molecular Biology, Part B2017 212, 59-69. Link
25. Joshua K. Crowell; Sinjinee Sardar; Mohammad S. Hossain; Frank W. Foss Jr.; Brad S. Pierce* “Non-chemical proton-dependent steps prior to O2-activaiton limit Azotobacter vinelandii 3-mercaptopropionic acid dioxygenase (MDO) catalysis” Arch Biochem Biophys. 2016 604, 86-94. Link
24. Hannah M. Johnston; Philip M. Palacios; Brad S. Pierce; Kayla N. Green*; “Spectroscopic and solid state evaluations of tetra-aza macrocyclic cobalt complexes with parallels to the classic cobalt(II) chloride equilibrium” J Coord Chem.2016 69, 11-13, 1979-89. Link
23. Brad S. Pierce*; Bishnu P. Subedi; Sinjinee Sardar; Joshua K. Crowell; “The ‘Gln-type’ thiol dioxygenase from Azotobacter vinelandii is a 3-mercaptopropionic acid dioxygenase” Biochemistry2015 54(51):7477-90. Link
22. Kimberly M. Lincoln; Netzahualcóyotl Arroyo-Currás; Hannah M. Johnston; Travis D. Hayden; Brad S. Pierce; Nattamai Bhuvanesh; Kayla N. Green* “Chemical Characteristics of the Products of the Complexation Reaction Between Copper(II) and a tetra-aza Macrocyle in the Presence of Chloride Ions” J Coord Chem2015 (68) 16, 2810-26. Link
21. Punnamchandar Ramidi; Charlette M. Felton; Bishnu P. Subedi; Huajan Zhou; Z. Ryan Tian; Yashraj Gartia; Brad S. Pierce; Anindya Ghosh* “Synthesis and characterization of manganese(III) and high valent manganese-oxo amido -amine complexes and their roles in the single-pot catalytic conversion of alkenes to cyclic carbonates” Journal of CO2 Utilization2015 (9) 48-57. Link
20. Bishnu P. Subedi; Andra L. Corder; Siai Zhang; Frank W. Foss, Jr.; Brad S. Pierce* “Steady-state kinetics and spectroscopic characterization of enzyme-tRNA interactions for the non-heme diiron tRNA-monooxygenase, MiaE” Biochemistry2015 54(2): 363-76. Link
19. Wei Li and Brad S. Pierce* “Steady-state substrate specificity and O2-coupling efficiency of mouse cysteine dioxygenase” Arch Biochem Biophys. 2015 565: 49-56. Link
18. Joshua K. Crowell; Wei Li; Brad S. Pierce* “Oxidative uncoupling in cysteine dioxygenase is gated by a proton-sensitive intermediate” Biochemistry2014 53(48): 7541-8. Link
17. Thai Kabbua; Preeyanan Anwised; Atcha Boonmee; Brad S. Pierce; Bishnu P. Subedi; Apisak Dhiravisit; Sompong Thammasirirak* “Autoinduction, purification, and characterization of functional soluble α-globin chains of crocodile (Crocodylus siamensis) hemoglobin in Escherichia coli” Protein Expr Purif2014 Nov; 103: 56-63. Link
16. Tiffany A. Pinder; Steven K. Montalvo; Chung-Hung Hsieh; Allen M. Lunsford; Ryan D. Bethel; Brad S. Pierce; Marcetta Y. Darensbourg* ”Metallodithiolates as Ligands to Dinitrosyl Iron Complexes: Towards the Understanding of Structures, Equilibria, and Spin Coupling” Inorganic Chem. 2014; 53(17) 9095-9105. Link
15. Wei Li; Elizabeth J. Blaesi; Michael D. Pecore; Joshua K. Crowell; Brad S. Pierce* “Second-sphere interactions between the C93-Y157 cross-link and the substrate-bound Fe-site influence O2-coupling efficiency in mouse cysteine dioxygenase”; Biochemistry 2013 52 (51): 9104-9119. Link
14. Andra L. Corder; Bishnu P. Subedi; Siai Zhang; Amanda M. Dark; Frank W. Foss, Jr.; Brad S. Pierce* “Peroxide-shunt substrate-specificity for the Salmonella typhimurium O2-dependent tRNA modifying monooxygenase (MiaE)”; Biochemistry2013 52(36):6182-6196. Link
13. Joshua A. Crawford; Wei Li; Brad S. Pierce* “Single turnover of substrate-bound ferric cysteine dioxygenase (CDO) with superoxide anion: enzymatic reactivation, product formation, and a transient intermediate” Biochemistry, 2011, 50 (47), pp 10241–10253. Link
12. Paul J. Riedel; Thomas K. Mahle; Joshua A. Crawford; David M. Granum; Chelsea M. Wyss; Navamoney Arulsamy; Brad S. Pierce; Mark P. Mehn* “Sterically Encumbered b-Ketoaminate Complexes of Iron(II) and Zinc(II)” Dalton Trans. 2011;40(22):5881-90. Link
11. Shane Z. Sullivan; Anindya Ghosh*; Alexandru S. Biris; Sharon Pulla; Anna M. Brezden; Samulel L. Collom; Ross M. Woods; Pradip Munshi; Laura Schnackenberg; Brad S. Pierce; Ganesh K. Kannarpady “Fe-complex of a tetraamido macrocyclic ligand: Spectroscopic characterization and catalytic oxidation studies” Chem Phys Lett2010 (498) 359-365. Link
10. Jessica D. Gardner; Brad S. Pierce; Brian G. Fox; Thomas C. Brunold* “Spectroscopic and Computational Characterization of Substrate-Bound Mouse Cysteine Dioxygenase: Nature of the Ferrous and Ferric Cysteine Adducts and Mechanistic Implications” Biochemistry2010 (49) 6033-6041. Link
9. Michelle Oppenheimer; Brad S. Pierce; Joshua A. Crawford; Keith Ray; Richard R. Helm; Pablo Sobrado* “Recombinant expression, purification, and characterization of ThmD, the oxidoreductase component of tetrahydrofuran monooxygenase” Arch Biochem Biophys. 2010 492(2); 423-31. Link
ǂ8. Lucas J. Bailey; Nathaniel L. Elsen; Brad S. Pierce; Brian G. Fox* “Soluble Expression and Purification of the Oxidoreductase Component of Toluene-4-Monooxygenase” Protein Expr Purif. 2008 Jan; 57 (1): 9-16. Link
ǂ7. Brad S. Pierce*, Jessica D. Gardner, Lucas J. Bailey, Thomas C. Brunold, and Brian G. Fox “Characterization of the Nitrosyl Adduct of Substrate-Bound Mouse Cysteine Dioxygenase by Electron Paramagnetic Resonance: Electronic Structure of the Active Site and Mechanistic Implications” Biochemistry2007 46(29) 8569-78. Link
ǂ6. George N. Phillips, Jr., Brian G. Fox, John L. Markley, Euiyoung Bae, Eduard Bitto, Craig A . Bingman, Ronn Frederick, Jason McCoy, Brad Pierce, Jikui Song, Brian Volkman* “Structures off Proteins of Biomedical Interest from the Center for Eukaryotic Structural Genomics” J. Struct Funct Genomics. 2007 Sep;8(2-3):73-84. Link
ǂ5. Brad S. Pierce; Michael P. Hendrich* “Local and Global Effects of Metal Binding Within the small Subunit of Ribonucleotide Reductase” J Am Chem Soc.2005 127 (10); 3613-3623. Link
ǂ4. Brad S. Pierce; Timothy E. Elgren; Michael P. Hendrich* “Mechanistic Implications for the Formation of the Diiron Cluster in Ribonucleotide Reductase Provided by Quantitative EPR Spectroscopy” J Am Chem Soc.2003, 125 (29), 8748-8759. Link
ǂ3. David M. Arciero; Brad S. Pierce; Michael P. Hendrich; Alan B. Hooper* “Nitrosocyanin, a Red Cupredoxin-like Protein from Nitrosomonas europaea” Biochemistry2002; 41 (6); 1703-1709 (Accelerated Publication). Link
ǂ2. Dongwhan Lee; Brad Pierce; Carsten Krebs; Michael P. Hendrich; Boi Hanh Huynh; Stephan J. Lippard* “Functional Mimic of Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Mechanistic Implication of Paramagnetic Intermediates in the Reactions between Diiron(II) Complexes and Dioxygen” J Am Chem Soc.2002, 124 (15) 3993-4007. Link
ǂ1. Dongwhan Lee; Jennifer L. DuBois; Brad Pierce; Britt Hedman; Keith O. Hodgson; Michael P. Hendrich; Stephan J. Lippard* “Structural and Spectroscopic Studies of Valence-Delocalized Diiron(II,III) Complexes Supported by Carboxylate-Only Bridging Ligands” Inorganic Chemistry, 2002, 41 (12), 3172-3182. Link
ǂPapers prior to independent career; *Corresponding author