Publications
Select publications
- Higgins MA, Tegl G, MacDonald SA, Arnal G, Brumer H, Withers SG, Ryan KS. (2021) N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes. ACS Chem. Biol. 16(4):701-711. DOI: 10.1021/acschembio.0c00995
- Higgins MA, Ryan KS. (2021) Generating a fucose permease deletion mutant in Bifidobacterium longum subspecies infantis ATCC 15697. Anaerobe. 68:102320. DOI: 10.1016/j.anaerobe.2021.102320.
- Beskrovnaya P, Melnyk RA, Liu Z, Liu Y, Higgins MA, Song Y, Ryan KS, Haney CH. (2020) Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility. (2020) mBio. 11(3):e00575-20. DOI: 11(3):e00575-20.
- Du, Y.-L., Higgins, M.A., Zhao, G., Ryan K.S. (2019) Convergent biosynthetic transformations to a bacterial specialized metabolite. Nat. Chem. Biol. 15, 1043-1048. DOI: 10.1038/s41589-019-0331-5.
- Guo J, Higgins MA, Daniel-Ivad P, Ryan KS. (2019) An Asymmetric Reductase that Intercepts Acyclic Imino Acids Produced In Situ by a Partner Oxidase. J. Am. Chem. Soc. 141(31):12258-12267. DOI: 10.1021/jacs.9b03307.
- Du, Y.-L., He, H.Y., Higgins M.A. & Ryan, K.S. (2017) A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate. Nat. Chem. Biol. 13, 836-838. DOI: 10.1038/nchembio.2411.
- Day CJ, Paton AW, Higgins MA, Shewell LK, Jen FE, Schulz BL, Herdman BP, Paton JC, Jennings MP. (2017) Structure aided design of a Neu5Gc specific lectin. Sci Rep. 7(1):1495. DOI: 10.1038/s41598-017-01522-9.
- Mahdi LK†, Higgins MA†, Day CJ, Tiralongo J, Hartley-Tassell LE, Jennings MP, Gordon DL, Paton AW, Paton JC, Ogunniyi AD. The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates. EBioMedicine. 8:236-243. (2017) DOI: 10.1016/j.ebiom.2017.03.002.
- Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Samain E, Boraston ABB, Kizhakkedathu JN, Withers SG. (2015) Toward efficient enzymes for the generation of universal blood through structure-guided directed evolution. J Am Chem Soc. 137(17):5695-705. DOI: 10.1021/ja5116088.
- Shewell LK†, Harvey RM†, Higgins MA, Day CJ, Hartley-Tassell LE, Chen AY, Gillen CM, James DB, Alanzo III F, Torres VJ, Paton AW, Paton JC, Jennings M. (2014) The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity. Proc Natl Acad Sci U S A. 111(49):E5312-20. DOI: 10.1073/pnas.1412703111.
- Higgins MA, Suits MD, Marsters C, Boraston AB. (2014) Structural and functional analysis of fucose processing enzymes from Streptococcus pneumoniae. J Mol Biol. 2014 Apr 3;426(7):1469-82. DOI: 10.1016/j.jmb.2013.12.006.